Interference with Tripartite Motif-Containing Protein 26 Expression on Proliferation of Glioma Cells

نویسندگان

چکیده

This research aims to study the effect of interference with tripartite motif-containing protein 26 expression on proliferation intracranial glioma cells. randomly selected 60 cases specimens and brain tissue 10 trauma patients as a normal control group. First, cell culture is performed observe growth status Subsequently, small interfering ribonucleic acid technique was used interfere lines A172 U251 The cells were collected for 26, Western blot fluorescence quantitative polymerase chain reaction verify knockout effect, proliferation, clone formation, transfer, invasion experiments performed. Experimental data showed that among patients, samples positive in 46 all negative. performance compared tissue. difference statistically significant (p<0.01). results show can reduce level pre-B-cell leukemia homeobox through correlation time gradient concentration gradient. Tripartite messenger ring finger 6 downstream target gene without affecting homeobox.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Tripartite motif containing 25 promotes proliferation and invasion of colorectal cancer cells through TGF-β signaling

Tripartite motif containing 25 (TRIM25) is a member of TRIM proteins and functions as an E3 (ubiquitin ligase). It has been found to act as an oncogene in gastric cancer cells and is abnormally expressed in cancers in female reproductive system. Here, we investigated the function of TRIM25 in colorectal cancer. TRIM25 was found to be significantly up-regulated in colorectal cancer tissues and c...

متن کامل

Tripartite Motif-Containing 29 Expression in Squamous Cell Carcinoma

Received August 9, 2012, Revised September 3, 2012, Accepted for publication September 9, 2012 Corresponding author: Moon-Kyun Cho, M.D., Department of Dermatology, Soonchunhyang University Seoul Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul 140-743, Korea. Tel: 82-2-709-9368, Fax: 82-2-709-9374, E-mail: [email protected] This is an Open Access article distributed under the terms of the Crea...

متن کامل

Correction: Tripartite Motif-Containing Protein 30 Modulates TCR-Activated Proliferation and Effector Functions in CD4+ T Cells

To avoid excessive activation, immune signals are tightly controlled by diverse inhibitory proteins. TRIM30, a tripartite motif (TRIM)-containing protein is one of such inhibitors known to function in macrophages. To define the roles of TRIM30, we generated Trim30 knockout (Trim30-/-) mice. Trim30 deletion caused no major developmental defects in any organs, nor showed any discernable defect in...

متن کامل

TRIM 37 ( tripartite motif - containing 37 )

Hugo: TRIM37 Other names: MUL; KIAA0898; POB1; TEF3 Location: 17q23.2 Local order: Genes flanking TRIM37 oriented from centromere to telomere on 17q23 are: RAD51C, 17q22-q23, D51 homolog C (S. Cerevisiae) PPM1E, 17q23.2, protein phosphatase 1E (PP2C domain containing) TRIM37, 17q22-q23, tripartite motif-containing 37 FAM33A 17q23.2, family with sequence similarity 33, member A PRR11(FLJ11029) 1...

متن کامل

The tripartite motif-containing protein 3 on the proliferation and cytokine secretion of rheumatoid arthritis fibroblast-like synoviocytes

Recent studies have revealed fibroblast-like synoviocytes (FLS) as a pivotal effector cell in the inflamed joint of rheumatoid arthritis (RA) patients. FLS exhibit high proliferation rates and constitutive expression of cytokines, contributing to the pathogenesis of RA. In this study, we found that the expression of tripartite motif-containing protein 3 (TRIM3), a candidate tumor suppressor gen...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Indian Journal of Pharmaceutical Sciences

سال: 2022

ISSN: ['0250-474X', '1998-3743']

DOI: https://doi.org/10.36468/pharmaceutical-sciences.spl.562